Publications
2026
- Kase et al. 2026 – Immune checkpoint inhibitors affect the potency of chemotherapeutic drugs in head and neck squamous cell carcinoma lines
- Muhandiram et al. 2026 – Trophoblast derived extracellular vesicles trigger secondary vesicle release from endometrial epithelial cellsSemaglutide alters the human embryo–endometrium interface
- Apostolov et al. 2026 – Semaglutide alters the human embryo–endometrium interface
- Vavers et al. 2026 – Simultaneous Expression of Sigma-1 Receptor and Tetraspanins Highlights Pathways of Receptor Sorting Into Extracellular Vesicles
- Laasfeld et al. 2026 – Kinetic assays to characterize fluorescent ligand binding to muscarinic acetylcholine M1 receptor
- Sadam et al. 2026 – Maternal antibodies shape infant immune response development in an epitope-specific manner
- Mousavi et al. 2026 – Milk-Derived Extracellular Vesicles Protect Bovine Oviduct Epithelial Cells from Oxidative Stress
DataDOI:
- Laasfeld et al. 2026 – UT-GPCR005 Fluorescence anisotropy time-series of competition binding between unlabeled ligands of M1 muscarinic acetylcholine receptor and TAMRA labeled UR-MK342
2025
- Nasirova et al. 2025 – Shifting focus in the Bradford assay: interfering compounds re-examined
- Abbondanza et al. 2025 – Dissection of Neurochemical Pathways Across Complexity and Scale
- Ullrich et al. 2025 – Discovery of a functionally selective serotonin receptor (5-HT1AR) agonist for the treatment of pain
- Laasfeld et al. 2025 – A bio. tools collection of online resources for GPCR research
- Leis et al. 2025 – Proteome changes associated with effect of high-dose single-fractionation radiation on lung adenocarcinoma cell lines
2024
- Lavõgina et al. 2024 – Hypoxic conditions affect transcriptome of endometrial stromal cells in endometriosis and promote TGFBI axis
- Gnilitskyi et al. 2024 – Enhanced osteointegration and osteogenesis of osteoblast cells by laser-induced surface modification of Ti implants
- Ertl et al. 2024 – Dually Labeled Neurotensin NTS1R Ligands for Probing Radiochemical and Fluorescence-Based Binding Assays
- Visser et al. 2024 – Epidemiologically relevant phthalates affect human endometrial cells in vitro through cell specific gene expression changes related to the cytoskeleton and mitochondria
- Allikalt et al. 2024 – MultiBacMam Technology for Studying the Downstream cAMP Signaling Pathway of M2 Muscarinic Acetylcholine Receptor
- Laasfeld et al. 2024 – Exploring Muscarinic Acetylcholine Receptor Binding Kinetics with Fluorescence Anisotropy
- Ernits et al. 2024 – Microfluidic production, stability and loading of synthetic giant unilamellar vesicles
- Lavõgina et al. 2024 – Phthalate monoesters affect membrane fluidity and cell-cell contacts in endometrial stromal cell lines
- Gleixner et al. 2024 – Illuminating Neuropeptide Y Y4 Receptor Binding: Fluorescent Cyclic Peptides with Subnanomolar Binding Affinity as Novel Molecular Tools
- Lavõgina et al. 2024 – ExplORRNet: An interactive web tool to explore stage-wise miRNA expression profiles and their interactions with mRNA and lncRNA in human breast and gynecological cancers
- Lavõgina et al. 2024 – Inhibition of epigenetic and cell cycle-related targets in glioblastoma cell lines reveals that onametostat reduces proliferation and viability in both normoxic and hypoxic conditions
2023
- Saar et al. 2023 – Exploring the Molecular Players behind the Potentiation of Chemotherapy Effects by Durvalumab in Lung Adenocarcinoma Cell Lines
- Tarvainen et al. 2023 – Identification of phthalate mixture exposure targets in the human and mouse ovary in vitro
- Tahk et al. 2023 – Fluorescence based HTS-compatible ligand binding assays for dopamine D3 receptors in baculovirus preparations and live cells
- Lavõgina et al. 2023 – Conjugates of adenosine mimetics and arginine-rich peptides serve as inhibitors and fluorescent probes but not as long-lifetime photoluminescent probes for protein arginine methyltransferases
- Saar et al. 2023 – Immune checkpoint inhibitors modulate the cytotoxic effect of chemotherapy in lung adenocarcinoma cells
- Vavers et al. 2023 – Sigma-1 receptor and seizures
2022
- Tahk et al. 2022 – Live-cell microscopy or fluorescence anisotropy with budded baculoviruses-which way to go with measuring ligand binding to M4 muscarinic receptors?
- Ali et al. 2022 – ArtSeg—Artifact segmentation and removal in brightfield cell microscopy images without manual pixel-level annotations
- Lavõgina et al. 2022 – Revisiting the Resazurin‐Based Sensing of Cellular Viability: Widening the Application Horizon
- Kopanchuk et al. 2022 – Intracellular dynamics of the Sigma-1 receptor observed with super-resolution imaging microscopy
- Müller et al.. 2022 – Structure-Based Design of High-Affinity Fluorescent Probes for the Neuropeptide Y Y1Receptor
- Pikma et al. 2022 – The effect of substituents on carbon–carbon double bond isomerization in heterocyclic hydrazine derivatives
- Matulienė et al. 2022 – Picomolar fluorescent probes for compound affinity determination to carbonic anhydrase IX expressed in live cancer cells
- Lavõgina et al. 2022 – Endocrine disrupting chemicals interfere with decidualization of human primary endometrial stromal cells in vitro
DataDOI:
- Tahk et al. 2022 – UT-GPCR004 CHO-K1 cell line bright-field and fluorescence microscopy and corresponding segmentation ground truth
- Tahk et al. 2022 – UT-GPCR003 Fluorescence anisotropy and microscopy measurements experimental metadata of ligand binding to M4 muscarinic receptors
- Tahk et al. 2022 – UT-GPCR002 Machine learning models for CHO-K1 cell segmentation from fluorescence and bright-field microscopy images
- Tahk et al. 2022 – UT-GPCR001 microscopy of ligand binding to M4 muscarinic receptor in live CHO-K1-hM4 cells
- Ali et al. 2022 – ArtSeg-CHO-M4R: artifact segmentation in microscopy of ligand binding to M4 muscarinic receptor in live CHO-K1-hM4 cells.
2021
- Lingsamy et al. 2021 – Pl1 peptide engages acidic surfaces on tumor-associated fibronectin and tenascin isoforms to trigger cellular uptake
- Saar et al. 2021 – Expression of immune checkpoint pd-1 in non-small cell lung cancer is associated with tumor cell dna-dependent protein kinase
- Lavõgina et al. 2021 – Viability fingerprint of glioblastoma cell lines: roles of mitotic, proliferative, and epigenetic targets
- Lavõgina et al. 2021 – Progesterone triggers Rho kinase-cofilin axis during in vitro and in vivo endometrial decidualization
- Khatun et al. 2021 – Decidualized endometrial stromal cells present with altered androgen response in PCOS
- Grätz et al. 2021 – BRET- and fluorescence anisotropy-based assays for real-time monitoring of ligand binding to M2 muscarinic acetylcholine receptors
- Laasfeld et al. 2021 – Budded baculoviruses as a receptor display system to quantify ligand binding with TIRF microscopy
- Veiksina et al. 2021 – Fluorescence Anisotropy-based Assay for Characterization of Ligand Binding Dynamics to GPCRs: The Case of Cy3B-Labeled Ligands Binding to MC4 Receptors in Budded Baculoviruses
- Fishman et al. 2021 – Practical segmentation of nuclei in brightfield cell images with neural networks trained on fluorescently labelled samples
- Lavõgina et al. 2021 – cAMP Biosensor Assay Using BacMam Expression System: Studying the Downstream Signaling of LH/hCG Receptor Activation
2020
- Ehrminger et al. 2020 – Characterizing the biofunctionalization of gold surface with total internal reflection fluorescence (TIRF) microscopy
- Midekessa et al. 2020 – Zeta Potential of Extracellular Vesicles: Toward Understanding the Attributes that Determine Colloidal Stability
- Allikalt et al. 2020 – Quantitative analysis of fluorescent ligand binding to dopamine D3 receptors using live cell microscopy
- Khatun et al. 2020 – Women with polycystic ovary syndrome present with altered endometrial expression of stanniocalcin-1
- Nonga et al. 2020 – Discovery of strong inhibitory properties of a monoclonal antibody of PKA and use of the antibody and a competitive photoluminescent orthosteric probe for analysis of the protein kinase
- Lingasamy et al. 2020 – Tumor-penetrating peptide for systemic targeting on Tenascin-C
2019
- Link et al. 2019 – The constitutive activity of melanocortin-4 receptors in cAMP pathway is allosterically modulated by zinc and copper ions
- Asciutto et al. 2019 – A Phage Display-Derived Peptide Binds To Human CD206 And Modeling Reveals A New Binding Site In The Receptor
- Koistinen et al. 2019 – Hyperglycosylated hCG activates LH/hCG-receptor with lower activity than hCG
- Lavõgina et al. 2019 – Chemosensitivity and chemoresistance in endometriosis – differences for ectopic versus eutopic cells
- Khatun et al. 2019 – Women with polycystic ovary syndrome present with altered endometrial expression of stanniocalcin-1
- Sõrmus et al. 2019 – Efficient photocaging of a tight-binding bisubstrate inhibitor of cAMP-dependent protein kinase
- Viirlaid et al. 2019 – Immunoassay for rapid on-site detection of glyphosate herbicide
2018
- Juronen et al. 2018 – Immunosensing system for rapid multiplex detection of mastitis-causing pathogens in milk
- Lavogina et al. 2018 – Dissection of Protein Kinase Pathways in Live Cells Using Photoluminescent Probes: Surveillance or Interrogation?
- Rinken et al. 2018 – Assays with Detection of Fluorescence Anisotropy: Challenges and Possibilities for Characterizing Ligand Binding to GPCRs
- Allikalt et al. 2018 – Implementation of fluorescence anisotropy-based assay for the characterization of ligand binding to dopamine D1 receptors
2017
- Mazina et al. 2017 – Determination of biological activity of gonadotropins hCG and FSH by Förster resonance energy transfer based biosensors
- Link et al. 2017 – Characterization of ligand binding to melanocortin 4 receptors using fluorescent peptides with improved kinetic properties
- Tekko et al. 2017 – Wfs1 is expressed in dopaminoceptive regions of the amniote brain and modulates levels of D1-like receptors
- Allikalt, Rinken 2017 – Budded baculovirus particles as a source of membrane proteins for radioligand binding assay: The case of dopamine D1 receptor
- Sinijärv et al. 2017 – Binding assay for characterization of protein kinase inhibitors possessing sub-picomolar to sub-millimolar affinity
- Laasfeld et al. 2017 – Image-based cell-size estimation for baculovirus quantification
- Rahnel et al. 2017 – A Selective Biligand Inhibitor of CK2 Increases Caspase-3 Activity in Cancer Cells and Inhibits Platelet Aggregation
- Schodeller et al. 2017 – Precision Targeting of Tumor Macrophages with a CD206 Binding Peptide
2016
- Rinken et al. 2016 – Dynamics of ligand binding to GPCR: Residence time of melanocortins and its modulation
2015
- Hoffmann et al. 2015 – Ligand Residence Time at G-protein–Coupled Receptors — Why We Should Take Our Time To Study It
- van Unen et al. 2015 – A perspective on studying GPCR signaling with RET biosensors in living organisms
- Mazina et al. 2015 – Characterization of the Biological Activities of Human Luteinizing Hormone and Chorionic Gonadotropin by a Förster Resonance Energy Transfer-Based Biosensor Assay
- Mazina et al. 2015 – cAMP Assay for GPCR Ligand Characterization: Application of BacMam Expression System
- Veiksina et al. 2015 – Homogeneous Fluorescence Anisotropy-Based Assay for Characterization of Ligand Binding Dynamics to GPCRs in Budded Baculoviruses: The Case of Cy3B-NDP-α-MSH Binding to MC4 Receptors
2014
- Pikker et al. 2014 – Gilded nanoparticles for plasmonically enhanced fluorescence in TiO2:Sm3+ sol-gel films
- Tõntson et al. 2014 – Characterization of 5-HT1A receptors and their complexes with G-proteins in budded baculovirus particles using fluorescence anisotropy of Bodipy-FL-NAN-190
- Veiksina et al. 2014 – Budded baculoviruses as a tool for a homogeneous fluorescence anisotropy-based assay of ligand binding to G protein-coupled receptors: The case of melanocortin 4 receptors
2013
- Tõntson et al. 2013 – Biarsenical ligands bind to endogenous G-protein α-subunits and enable allosteric sensing of nucleotide binding
- Dzirkale et al. 2013 – Lunasin-induced behavioural effects in mice: focus on the dopaminergic system
- Mazina et al. 2013 – Application of Baculovirus Technology for Studies of G Protein-Coupled Receptor Signaling
- Reinart-Okugbeni et al. 2013 – 1-substituted apomorphines as potent dopamine agonists
2012
- Reinart-Okugbeni et al. 2012 – Chemoenzymatic synthesis and evaluation of 3-azabicyclo[3.2.0]heptane derivatives as dopaminergic ligands
- Mazina et al. 2012 – BacMam System for FRET-Based cAMP Sensor Expression in Studies of Melanocortin MC1 Receptor Activation
- Tõntson et al. 2012 – Characterization of heterotrimeric nucleotide-depleted Gαi-proteins by Bodipy-FL-GTPγS fluorescence anisotropy
2011
- Reinart-Okugbeni et al. 2011 – New 2-thioether-substituted apomorphines as potent and selective dopamine D2 receptor agonists
- Matrov et al. 2011 – Activating Effects of Chronic Variable Stress in Rats with Different Exploratory Activity: Association with Dopamine D1 Receptor Function in Nucleus Accumbens
- Parkel et al. 2011 – Millimolar Mn2+ influences agonist binding to 5-HT1A receptors by inhibiting guanosine nucleotide binding to receptor-coupled G-proteins
2010
- Veikšina et al. 2010 – Fluorescence anisotropy assay for pharmacological characterization of ligand binding dynamics to melanocortin 4 receptors
2009
- Herm et al. 2009 – N-Substituted-2-alkyl- and 2-arylnorapomorphines: Novel, highly active D2 agonists
- Parkel et al. 2009 – Enhancement of agonist binding to 5-HT1A receptors in rat brain membranes by millimolar Mn2+
- Kalda et al. 2009 – Co-administration of the partial dopamine D2 agonist terguride with L-dopa attenuates L-dopa-induced locomotor sensitization in hemiparkinsonian mice
2008
- Pulges et al. 2008 – α2A-Adrenoceptor-specific Stimulation of [35S]GTPγS Binding to Membrane Preparations of Rat Frontal Cortex
- Sipos et al. 2008 – Synthesis and neuropharmacological characterization of 2-O-substituted apomorphines
- Vonk et al. 2008 – Modulation of Adenylyl Cyclase Activity in Rat Striatal Homogenate by Dopaminergic Receptors
- Rudissaar et al. 2008 – Repeated administration of the dopaminergic agonist apomorphine: development of apomorphine aggressiveness and changes in the interaction between dopamine D2 receptors and G-proteins
- Mällo et al. 2008 – Regulation of extracellular serotonin levels and brain-derived neurotrophic factor in rats with high and low exploratory activity
- Tõnissaar et al. 2008 – Rats with high or low sociability are differently affected by chronic variable stress
2007
- Alttoa et al. 2007 – Amphetamine-induced locomotion, behavioral sensitization to amphetamine, and striatal D2 receptor function in rats with high or low spontaneous exploratory activity: Differences in the role of locus coeruleus
- Rinken et al. 2007 – Production of Biosensors with Exchangeable Enzyme−Containing Threads
- Mällo et al. 2007 – Tickling-induced 50-kHz ultrasonic vocalization is individually stable and predicts behaviour in tests of anxiety and depression in rats
2006
- Kopanchuk et al. 2006 – Kinetic evidence for tandemly arranged ligand binding sites in melanocortin 4 receptor complexes
- Uustare et al. 2006 – Modulation of dopamine D1 receptor signaling by adenosine A1 receptors in Sf9 cells requires expression of Gi proteins
- Parkel et al. 2006 – Characteristics of Binding of [3H]WAY100635 to Rat Hippocampal Membranes
- Tõnissaar et al. 2006 – Individual differences in sucrose intake and preference in the rat: Circadian variation and association with dopamine D2 receptor function in striatum and nucleus accumbens
- Saal et al. 2006 – Sol–gel films for DNA microarray applications