GPCR – what is it

G-protein coupled receptors (GPCRs) are a family of protein receptors which are expressed on the cell membrane. GPCRs can transduct several different kind of extracellular signals to the intracellular space, which in turn can activate numerous different signalling pathways which lead to cellular responses. Problems with signal transduction process can lead to various diseases and thus GPCRs are important biological targets for drugs. 
Our reasearch group is foucused on several different receptors and is engaged in studying both extracellular and intracellular effects of receptor activation mechanisms.


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Beta2-adrenergic receptor PDB ID: 5D5B

Our Targets:

  • Melanocortin: MC1, MC3, MC4, MC5
  • Dopamine: D1, D2, D3, D4, D5
  • Muscarinic acetylcholine : M1, M2, M3, M4, M5
  • Serotonin: 5-HT-1A, 5-HT-2A, 5-HT-7
  • Sigma: σ1
  • Adenosine: A1, A2A, A2B, A3
  • Recent additions
    • FZD6, NPY, Orexin 1, Endothelin1A, GPR155 (orphan)

 our focus: Receptor Binding and activation mechanisms

Effects on extracellular side of a receptor

  • Binding studies on abovementioned GPCRs using fluorescent and radioactively labelled ligands using spectroscopy and microscopy techniques

 Effects on intracellular side of a receptor

Our Methods:

Cooperation, Equipment and Software

Visit collaboration page for further details about our partners.
​Visit equipment page for further details about the instruments in our lab.
Visit software page for downloads and further details about the software being developed in our lab.